Associate Research Fellow and Research Fellow in Deep Raman for Novel Breast Disease Diagnostics

Job title: Associate Research Fellow/Research Fellow
Employer: College of Engineering, Mathematics and Physical Sciences- Biomedical Physics - School of Physics and Astronomy, Exeter
Application closing date: 17/04/2013
Salary: £24,766 (29.023€) per annum on Grade E up to £34,223 (40.118€) per annum on Grade F
Package: Generous holiday allowances, flexible working, pension scheme, car lease scheme and relocation package (if applicable)
Job category/type: Research
Job description Associate Research Fellow/Research Fellow in Deep Raman for Novel Breast Disease Diagnostics

These full-time posts are available from 01 July 2013 on a fixed term basis for 36 months.

The College wishes to recruit an Associate Research Fellow and Research Fellow to participate in the project entitled 'A novel Deep Raman spectroscopy platform for non-invasive in situ molecular analysis of disease specific tissue compositional changes'. These EPSRC funded posts are available from 01 July 2013 for 36 months. The successful applicants will undertake research into the development of novel deep Raman systems for use in vivo for the real-time detection and diagnosis of breast cancers and surgical targeting within the breast. The technique will utilise near-infrared light to probe the disease specific molecular composition of breast tissue and associated lymph nodes in vivo and in real-time using transmission and spatially offset (SORS) Raman spectroscopy.

The postholders will be required to develop novel sampling configurations and optical designs, measure tissue optical properties and develop models for photon migration, test the designs both in the non-clinical environment initially and then in the clinical environment with ex vivo tissues. This will involve some optical modelling; development and manufacture of optimum designs; spectral measurement of clinical samples; and developing and testing of multivariate diagnostic algorithms to discriminate disease conditions using the probes. The applicants will be expected to undertake detailed Raman spectral analysis of tissues measured and develop new methodologies leading to prototype clinical instruments for in vivo molecular diagnosis.

The positions will be based in the Stone lab at Exeter, with close engagement with the Matousek lab at STFC Rutherford Appleton Laboratory in Oxfordshire. It will also involve working when appropriate with local clinical teams to develop the technique for real-world applications. This will require communication with multidisciplinary teams and individuals of all backgrounds. The successful applicant will be able to present information on research progress and outcomes, communicate complex information, orally, in writing and electronically and prepare proposals and applications to external bodies.

Applicants will possess a relevant PhD and be able to demonstrate sufficient knowledge in the discipline and of research methods and techniques to work within established research programmes. Applicants should be skilled in vibrational spectroscopy and ideally have experience in instrumental development, mathematical modelling and measuring biomedical spectra.

For further information please contact Prof. Nick Stone, e-mail n.stone@ex.ac.uk or telephone (01392) 726531.

The College is working towards department Silver Athena SWAN awards as a commitment to providing equality of opportunity and advancing the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.

To view the Job Description and Person Specification document please click here.

Interviews are expected to take place late April / early May 2013.

The University of Exeter is an equal opportunity employer which is 'Positive about Disabled People'. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce.

How to apply for this position

Please send your completed application and equal opportunities form along with your CV, covering letter and the details of three referees, to Prof Nick Stone, e-mail n.stone@ex.ac.uk quoting the reference number P44865 in any correspondence.

To download the application and equal opportunities form please follow the below links:

http://www.admin.ex.ac.uk/personnel/jobs/ app_form.rtf

http://www.admin.ex.ac.uk/personnel/jobs/EO_form.rtf

Round Robin Experiment

Raman spectroscopy has already proved its effectiveness in many cases for medical diagnostics such as for cancer, cardiovascular diseases and infections. However, there are no standards in the different working groups, e.g. for sample preparation, implementation of the Raman experiments, spectra pre-treatment, data evaluation, etc.In a round robin experiment, the required groundwork will take place in order to define standardised Raman measurement methods, which will be fundamental for establishing Raman spectroscopy for clinical diagnostic procedures.

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