University of Twente

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The MESA+ Institute for Nanotechnology is a spearhead institute at the University of Twente.The institute employs 475 people of which 275 are PhD‟s or postdocs. The institute holds 1250 m2 of cleanroom space and state of the art research equipment. MESA+ has an integral turnover of 40 million euro per year of which more than 60% is acquired in competition from external sources. MESA+ has been the breeding ground for more than 30 high-tech start-ups to date. A targeted program for cooperation with small and medium-sized enterprises is specially set up for start-ups.

MESA+ combines the disciplines of physics, electrical engineering, chemistry and mathematics. It is strengthening its international academic and industrial network by fruitful cooperation programs. The activities of the 23 participating research groups are focused in 5 central programmes, which are responsible for 70% of the total research volume within the institute. Activities in Biophotonics are represented in several ongoing research programmes. Internationally appealing research is achieved through this multidisciplinary approach. MESA+ is the largest nanotechnology institute within the Netherlands. MESA+ plays a leading role in the existing Dutch NanoNed program, and in defining the contours of the National Nanotechnology Initiative for the future.

Biophotonics related work is concentrated in the Biophysical Engineering Group (Prof. Vinod Subramaniam), but several other chairs have relevant activities, including the groups Laser Physics and Nonlinear Optics (Prof. Klaus Boller), Optical Sciences (Prof. Jennifer Herek), Complex Photonic Systems (Prof. Willem Vos), Integrated Optics and Microsystems (Prof. Markus Pollnau, Prof. Alfred Driessen). Research activities include:

Biophysical Engineering: nanoBiophotonics, hybrid imaging platform technologies, fluorescence lifetime imaging, Raman microscopy, CARS spectroscopy and imaging, nanomedical applications – ultrasensitive diagnostics, flow cytometry, nanoparticle assisted diagnostics, molecular imaging and therapy, photoacoustic imaging (tissue/small animal), non-invasive diagnostics and imaging (photoacoustic mammography, for example), ultrasound and laser Doppler approaches, optical tweezer nanomanipulation, single molecule science, scanning probe microscopy Optical Sciences: coherent control of biomolecules, CARS microscopy, near-field optics, single molecule spectroscopy

Laser Physics and Nonlinear Optics: research & development of sources and signal enhancement for optical trace gas detection (e.g. with mid-IR) in breath analysis, for mid-IR microscopy, rapidly tunable mid-IR photon tunneling microscope, sources for nonlinear microscopy (such as Raman, two-photon-Flourescence and STED), mid-IR plasmon based biosensors

Complex Photonic Systems: imaging through complex media, nanophotonics Integrated Optics and Microsystems: optical microsystems for biosensing, waveguide biosensors, research and development of solid-state sources


University of Twente
P.O. Box 217
7500 AE Enschede



Contact person

Prof. dr. Vinod Subramaniam


Round Robin Experiment

Raman spectroscopy has already proved its effectiveness in many cases for medical diagnostics such as for cancer, cardiovascular diseases and infections. However, there are no standards in the different working groups, e.g. for sample preparation, implementation of the Raman experiments, spectra pre-treatment, data evaluation, etc.In a round robin experiment, the required groundwork will take place in order to define standardised Raman measurement methods, which will be fundamental for establishing Raman spectroscopy for clinical diagnostic procedures.

Latest News

5th International Conference on Biophotonics

20 March 2017

Continuing the success of the previous meetings held in Sacramento, Ottawa, Jena, and Florence, the 5th conference will come to Perth, Western Australia, running over two full days, and back-to-back with the Science on the Swan medical research conference, which delegates are strongly encouraged to also attend, at discounted rates. [more]

Biophotonics Wiki

Visit our wiki to consult our latest technologies and techniques. [more]


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